Description

2H-Isoindole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and bicyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of new chemical entities and complex generics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained, three-dimensional scaffold.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up API synthesis under cGMP conditions.
• Academic Research: Employed in chemical biology and pharmacology studies to investigate ligand-receptor interactions.
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Item	Detail
Product Name	2H-Isoindole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci)
CAS No.	521280-16-0
Molecular Formula	C14H15N3O
Molecular Weight	241.29 g/mol
Synonyms	(1R,3R,4S)-3-[(2H-Isoindole-5-carbonyl)amino]-1-azabicyclo[2.2.1]heptane; (1R,3R,4S)-N-(1-Azabicyclo[2.2.1]hept-3-yl)-2H-isoindole-5-carboxamide; 1-Azabicyclo[2.2.1]hept-3-amine, N-(2H-isoindol-5-ylcarbonyl)-, (1R,3R,4S)-; 521280-16-0; (1R,3R,4S)-1-Azabicyclo[2.2.1]hept-3-yl 2H-isoindole-5-carboxylate amide
EINECS	Contact for details

Quality Control

Our 2H-Isoindole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a controlled humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.