Description

1H-Indazole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of potent, selective receptor ligands.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged scaffold.
• Ligand Synthesis: Serves as a precursor for the development of high-affinity ligands for various G-protein coupled receptors (GPCRs).
• Preclinical Development: Employed in the production of compounds for pharmacological profiling, toxicology studies, and early-stage clinical trial materials.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental research in neuropharmacology and chemical biology.

Basic Information

Product Name	1H-Indazole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci)
CAS No.	521277-98-5
Molecular Formula	C14H16N4O
Molecular Weight	256.31 g/mol
Synonyms	(1R,3R,4S)-3-[(1H-Indazol-5-yl)carbonyl]amino]-1-azabicyclo[2.2.1]heptane; (1R,3R,4S)-N-(1-Azabicyclo[2.2.1]hept-3-yl)-1H-indazole-5-carboxamide; 1H-Indazole-5-carboxamide, N-[(1R,3R,4S)-1-azabicyclo[2.2.1]hept-3-yl]-; 521277-98-5; (1R,3R,4S)-1-Azabicyclo[2.2.1]hept-3-amine, N-(1H-indazol-5-ylcarbonyl)-
EINECS	Contact for details

Quality Control

Our 1H-Indazole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.