Description

4-(Difluoromethoxy)Phenylacetylene is a high-value, functionalized aromatic alkyne building block. This compound is critical for advanced organic synthesis, particularly in the construction of complex molecules for pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences and specialty chemical industries for applications such as click chemistry, Sonogashira couplings, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, including potential kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides with enhanced properties.
• Material Science: Serves as a monomer or cross-linker in the synthesis of specialized polymers, liquid crystals, and advanced organic materials.
• Click Chemistry: An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole-linked compounds.
• Sonogashira Cross-Coupling: A versatile reagent for palladium-catalyzed coupling reactions with aryl or vinyl halides to form conjugated systems.
• Ligand Synthesis: Building block for creating novel ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(Difluoromethoxy)Phenylacetylene
CAS No.	519059-04-2
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	1-(Difluoromethoxy)-4-ethynylbenzene; 4-Ethynyl-α,α-difluoroanisole; p-(Difluoromethoxy)phenylacetylene; 1-Ethynyl-4-(difluoromethoxy)benzene; [4-(Difluoromethoxy)phenyl]acetylene
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Phenylacetylene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.