Description

3-(Difluoromethoxy)Phenylacetylen is a specialized fluorinated aromatic alkyne building block, identified by CAS number 519059-03-1. This high-value intermediate is critical for introducing the difluoromethoxy-phenyl moiety into complex molecular architectures, enabling precise modulation of physicochemical properties. It is primarily sought by R&D and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides where the difluoromethoxy group enhances bioavailability and stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in click chemistry and bioconjugation strategies to create fluorescent tags or affinity probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(Difluoromethoxy)Phenylacetylen
CAS No.	519059-03-1
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	3-(Difluoromethoxy)phenylacetylene; 1-Ethynyl-3-(difluoromethoxy)benzene; 3-Ethynyl-α,α-difluoroanisole; 3-(Difluoromethoxy)benzenecarbaldehyde; (3-(Difluoromethoxy)phenyl)ethyne
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Phenylacetylen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.