Description

2-Fluoro-4-Methylbenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to act as a sulfonylation reagent, introducing the sulfonyl functional group to create compounds with enhanced biological activity or specific material properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly in the development of active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides that require the sulfonyl moiety for activity.
• Chemical Research & Development: A valuable reagent in medicinal chemistry for creating compound libraries and exploring new chemical entities.
• Material Science: Employed in the synthesis of specialty polymers, dyes, and photoactive materials where the sulfonyl group modifies physical properties.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed coupling reactions to create complex biaryl structures.

Basic Information

Product Name	2-Fluoro-4-Methylbenzenesulfonyl Chloride
CAS No.	518070-29-6
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	4-Methyl-2-fluorobenzenesulfonyl chloride; 2-Fluoro-p-toluenesulfonyl chloride; 2-Fluoro-4-methylbenzene-1-sulfonyl chloride; 4-Methyl-2-fluorophenylsulfonyl chloride; 1-(Chlorosulfonyl)-2-fluoro-4-methylbenzene; 2-Fluoro-4-toluenesulfonyl chloride; 2-Fluoro-4-methylbenzenesulphonyl chloride; 518070-29-6
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.