Description

3-(Difluoromethoxy)Iodobenzene is a high-value fluorinated and halogenated aromatic building block, essential for advanced organic synthesis. Its unique structure, featuring both a difluoromethoxy group and an iodine atom, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the difluoromethoxy pharmacophore, which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its halogen and fluorine substituents.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for versatile palladium-catalyzed reactions, such as Suzuki, Sonogashira, and Heck couplings, enabling rapid diversification of molecular scaffolds.
• Labeling and Tracer Studies: Potential use in radiolabeling (with iodine-125 or iodine-131) for preclinical imaging and metabolic pathway studies in drug discovery.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for catalysis or as a substrate for developing new catalytic methodologies.

Basic Information

Product Name	3-(Difluoromethoxy)Iodobenzene
CAS No.	518070-17-2
Molecular Formula	C7H5F2IO
Molecular Weight	269.02 g/mol
Synonyms	1-Iodo-3-(difluoromethoxy)benzene; m-(Difluoromethoxy)iodobenzene; 3-Iodophenyl difluoromethyl ether; Benzene, 1-iodo-3-(difluoromethoxy)-; 518070-17-2; 3-Difluoromethoxy-1-iodobenzene
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Iodobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques, including GC, HPLC, NMR, and MS, for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and transfers should be minimized under direct light exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.