Description

Mal-Peg6-Acid CAS NO 518044-42-3 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a carboxylic acid at the other, connected by a hexaethylene glycol spacer. This compound is a critical reagent for creating stable, site-specific bioconjugates, enabling the precise attachment of biomolecules like peptides, proteins, and antibodies to various surfaces, drugs, or other functional molecules. It is essential for researchers and manufacturers in the fields of biopharmaceutical development, advanced drug delivery systems, and diagnostic assay production who require reliable, high-purity crosslinkers.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via thiol-maleimide chemistry.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to therapeutic proteins or peptides to improve solubility, stability, and pharmacokinetics.
• Surface Functionalization: Immobilization of biomolecules onto nanoparticles, biosensors, or microarray slides through the carboxylic acid group.
• Diagnostic Probe Synthesis: Conjugation of fluorescent dyes or other reporter molecules to targeting ligands for in vitro diagnostics.
• Hydrogel Formation: Crosslinking agent in the development of biocompatible hydrogels for tissue engineering and controlled release applications.
• Protein-Protein Crosslinking: Tool for studying protein interactions or creating multi-specific protein complexes.

Basic Information

Product Name	Mal-Peg6-Acid
CAS No.	518044-42-3
Molecular Formula	C25H41NO12
Molecular Weight	547.60 g/mol
Synonyms	Maleimide-PEG6-acid; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(17-carboxy-3,6,9,12,15-pentaoxaheptadec-1-yl)propanamide; Mal-PEG6-COOH; Maleimide-PEG6-Acid; 1-[17-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxa-17-oxoheptadecyl]-1H-pyrrole-2,5-dione (common misnomer); Maleimide hexaethylene glycol carboxylic acid; mPEG6-Mal-acid; NHS ester precursor
EINECS	Contact for details

Quality Control

Our Mal-Peg6-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistent performance for critical bioconjugation applications. Certificates of Analysis (COA) are provided with every shipment, detailing key parameters such as assay, identity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.