Description

2-Fluorobenzylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require fluorinated aromatic components.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where fluorinated units can tune electronic properties.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors.
• Catalyst & Ligand Development: Serves as a precursor for creating novel boron-containing ligands and catalysts for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Fluorobenzylboronic Acid Pinacol Ester
CAS No.	517920-60-4
Molecular Formula	C13H18BFO2
Molecular Weight	236.09 g/mol
Synonyms	2-Fluorobenzylboronic Acid Pinacol Ester; (2-Fluorophenyl)methylboronic Acid Pinacol Ester; 2-Fluorobenzylboronic Acid, Pinanediol Ester; 2-Fluoro-α-tolylboronic Acid Pinacol Ester; B-(2-Fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(2-fluorobenzyl)-1,3,2-dioxaborolane; 2-Fluorobenzyl-Bpin; 2-Fluorobenzyl MIDA Boronate (related protected form)
EINECS	Contact for details

Quality Control

Our 2-Fluorobenzylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and GC-MS, to verify identity and purity. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality management system is designed to meet the stringent requirements of research and development as well as cGMP for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.