Description

Fmoc-(R)-3-Amino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical chiral building block, enabling the precise incorporation of a trifluoromethylphenyl side chain into peptide sequences, which can significantly alter biological activity, metabolic stability, and lipophilicity. It is essential for medicinal chemists and researchers in pharmaceutical development, biotechnology, and academic institutions focused on creating novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide analogs and peptidomimetics for screening against biological targets, leveraging the unique properties of the trifluoromethyl group.
• Chemical Biology Research: Incorporation into peptide tags, substrates, or inhibitors to study enzyme function, protein-protein interactions, and cellular pathways.
• API Intermediate Development: Serves as a key chiral intermediate in the research and development stages of active pharmaceutical ingredients (APIs) with peptide backbones.
• Libraries for High-Throughput Screening (HTS): A valuable component for generating diverse combinatorial peptide libraries to identify new lead compounds.
• Material Science: Potential use in the synthesis of specialized polymers or surface modifiers where specific peptide sequences are required.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	517905-88-3
Molecular Formula	C26H22F3NO4
Molecular Weight	469.45 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(4-trifluoromethylphenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-[4-(trifluoromethyl)phenyl]-(R)-propionic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic Acid; Fmoc-3-Amino-3-(4-CF3-Ph)-Propionic Acid-(R); Fmoc-Atfmp-OH (common abbreviation); N-α-Fmoc-3-(4-Trifluoromethylphenyl)-(R)-β-homoalanine
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive research and development applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.