Description

5-Bromo-2-Isopropoxy-Benzonitrile is a high-purity, versatile benzonitrile derivative featuring a bromine substituent and an isopropoxy ether linkage. This compound serves as a critical advanced pharmaceutical intermediate and a valuable building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for its utility in cross-coupling reactions and as a precursor to functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging its halogenated aromatic structure.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions due to the reactive bromine atom.
• Chemical Research: Employed in academic and industrial R&D labs for method development and exploring new synthetic pathways in heterocyclic and medicinal chemistry.
• Ligand and Catalyst Development: Used to synthesize novel chelating ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	5-Bromo-2-Isopropoxy-Benzonitrile
CAS No.	515832-52-7
Molecular Formula	C10H10BrNO
Molecular Weight	240.10 g/mol
Synonyms	2-Isopropoxy-5-bromobenzonitrile; 5-Bromo-2-(1-methylethoxy)benzonitrile; 5-Bromo-2-isopropoxybenzonitrile; 2-(Propan-2-yloxy)-5-bromobenzonitrile; Benzonitrile, 5-bromo-2-(1-methylethoxy)-; 5-Bromo-2-isopropoxy phenyl cyanide; 515832-52-7 (CAS)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Isopropoxy-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to consistent quality and traceability supports your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.