Description

Prednisolone 21-β-D-Glucuronide is a key conjugated metabolite of the potent glucocorticoid prednisolone, formed via glucuronidation. This compound is of significant value as a high-purity reference standard for analytical and research applications, ensuring accurate quantification and metabolic profiling. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative analysis of prednisolone and its metabolites in biological matrices.
• Drug Metabolism Studies (DMPK): Used to investigate the metabolic pathways, pharmacokinetics, and excretion profiles of prednisolone in preclinical and clinical research.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic assays.
• Clinical Research & Toxicology: Employed in studies assessing corticosteroid metabolism, drug-drug interactions, and metabolic disorders.
• Quality Control & Assurance: Acts as a critical quality standard in the manufacturing and testing of pharmaceutical products containing corticosteroids.
• Academic Research: Utilized in university and institutional labs for biochemical research on steroid hormone conjugation and transport mechanisms.

Basic Information

Item	Details
Product Name	Prednisolone 21-β-D-Glucuronide
CAS No.	512165-95-6
Molecular Formula	C27H36O13
Molecular Weight	568.57 g/mol
Synonyms	Prednisolone 21-Glucuronide; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-β-D-Glucopyranosiduronic Acid; 21-(β-D-Glucopyranuronosyloxy)-11β,17α-dihydroxypregna-1,4-diene-3,20-dione; Prednisolone Glucuronide; Prednisolone 21-β-D-Glucopyranosiduronic Acid; PDN-G; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Prednisolone 21-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.