Description

Fmoc-(R)-3-Amino-3-(2-Fluoro-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a 2-fluorophenyl side chain, making it a critical chiral building block for advanced peptide synthesis. Its primary value lies in enabling the precise, automated synthesis of complex peptides and peptidomimetics with enhanced stability and specific biological activity. This compound is essential for researchers and manufacturers in pharmaceutical R&D, particularly in developing novel therapeutics, diagnostic agents, and bioactive probes where structural precision is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy in automated peptide synthesizers.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Incorporates fluorinated aromatic properties into synthetic peptides to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Bioconjugation & Probe Development: Serves as a building block for creating fluorescently labeled peptides, affinity tags, and other molecular probes for biochemical research.
• Combinatorial Chemistry Libraries: Used to introduce chiral diversity and fluorinated motifs into high-throughput screening libraries for drug discovery.
• Academic & Institutional Research: A valuable reagent for studies in medicinal chemistry, chemical biology, and structural biology.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(2-Fluoro-Phenyl)-Propionic Acid
CAS No.	511272-50-7
Molecular Formula	C24H20FNO4
Molecular Weight	405.42 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(2-fluorophenyl)propanoic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-fluorophenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-fluorophenyl)-D-alanine; Fmoc-D-2-Fluorophenylalanine; Fmoc-2-F-Phe-OH; Fmoc-2-F-D-Phe-OH; N-α-Fmoc-3-(2-fluorophenyl)-D-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(2-Fluoro-Phenyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including GMP-grade upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.