Description

Fmoc-(R)-3-Amino-3-(2-Thienyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a thienyl side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of peptides with unique structural and electronic properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key chiral intermediate for the automated synthesis of complex peptides containing unnatural amino acids.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, where the thienyl moiety can influence bioavailability, receptor binding, and metabolic stability.
• Chemical Biology Probes: Incorporated into peptide sequences to create probes for studying protein-protein interactions, enzyme activity, and cellular signaling pathways.
• Material Science: Potential use in the synthesis of peptidomimetics and functional polymers with specific electronic or self-assembly properties.
• Academic Research: Employed in organic chemistry and biochemistry laboratories for methodological studies and the synthesis of custom peptide libraries.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(2-Thienyl)-Propionic Acid
CAS No.	511272-45-0
Molecular Formula	C22H19NO4S
Molecular Weight	393.45 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(2-thienyl)propanoic acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid; Fmoc-(R)-3-(2-Thienyl)-β-alanine; Fmoc-(R)-β-(2-Thienyl)alanine; Fmoc-(R)-3-(2-Thienyl)alanine; Fmoc-(R)-Tpa(2-Thi)-OH; Fmoc-(R)-3-Amino-3-(2-thienyl)propionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-thienyl)-D-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(2-Thienyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.