Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Aniline is a high-value, multifunctional aromatic amine building block containing both a pinacol boronate ester and a trifluoromethyl group. This compound matters for its critical role in modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecules. Pharmaceutical, agrochemical, and advanced materials researchers need it to develop new active ingredients and functional materials with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those requiring the trifluoromethyl group for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the boronate ester facilitates efficient coupling to create diverse chemical scaffolds.
• Material Science: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic electronic materials (e.g., OLEDs, OFETs) due to its aromatic core and functional handles.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl/heteroaryl halides, a cornerstone reaction in medicinal and process chemistry.
• Chemical Biology & Proteomics: Can be utilized as a probe or linker in bioconjugation strategies and the development of chemical tools for studying biological systems.
• Custom Synthesis & Contract Research: A valuable starting material for custom synthesis houses and CROs (Contract Research Organizations) serving the life sciences industry.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Aniline
CAS No.	510771-54-7
Molecular Formula	C13H17BF3NO2
Molecular Weight	287.09 g/mol
Synonyms	3-Amino-5-(trifluoromethyl)phenylboronic acid pinacol ester; 5-(Trifluoromethyl)-3-aminophenylboronic acid pinacol ester; [3-Amino-5-(trifluoromethyl)phenyl]boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzenamine; 3-Pinacolatoboryl-5-(trifluoromethyl)aniline; 3-Borono-5-(trifluoromethyl)aniline pinacol ester; 3-Amino-5-trifluoromethylbenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.