Description

Catumaxomab is a trifunctional, bispecific monoclonal antibody designed for targeted cancer immunotherapy. Its primary value lies in its unique ability to simultaneously engage T-cells and tumor cells, facilitating a localized immune response against malignancies. This product is essential for pharmaceutical research and development, particularly in the fields of oncology and advanced therapeutic medicinal products (ATMPs). Catumaxomab CAS NO 509077-98-9 represents a critical reagent for developing and validating novel immunotherapeutic approaches.

Application

• Oncology Research: A key tool for studying bispecific antibody mechanisms, T-cell recruitment, and tumor cell killing in preclinical models.
• Immunotherapy Development: Serves as a reference standard or lead compound for developing next-generation bispecific and trifunctional antibodies.
• Biomarker Discovery: Used in assays to identify and validate EpCAM (Epithelial Cell Adhesion Molecule) as a target in various carcinomas.
• Process Development: Employed in downstream purification and analytical method development for monoclonal antibody manufacturing.
• Cell-Based Assays: Facilitates the study of antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis (ADCP).
• Academic Research: Used in university and institutional labs to investigate tumor immunology and novel cancer treatment modalities.

Basic Information

Product Name	Catumaxomab
CAS No.	509077-98-9
Molecular Formula	C6450H9936N1720O2010S44
Molecular Weight	~145 kDa
Synonyms	Removab; Anti-EpCAM x Anti-CD3 Trifunctional Antibody; Trifunctional Bispecific Antibody; Ertumaxomab (related); FBTA05; CD3/Epcam Bispecific Antibody; Trion Pharma Catumaxomab; Monoclonal Antibody Catumaxomab
EINECS	Contact for details

Quality Control

Our Catumaxomab is produced and tested under stringent quality management systems. Each batch is characterized for identity, purity, potency, and biological activity using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) is provided, detailing results for critical quality attributes including purity by SEC-HPLC, binding affinity (via SPR or ELISA), and endotoxin levels. We adhere to relevant ICH guidelines for biopharmaceuticals to ensure product consistency and reliability for research use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Content (UV)	≥ 90.0%
Biological Activity (Cell-based Assay)	EC50 within specified range
Endotoxin (LAL)	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile
Moisture Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.