Description

Fmoc-(S)-3-Amino-3-(2-Bromo-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This chiral building block is essential for introducing the unique 2-bromophenyl side chain into peptide sequences, enabling the development of novel bioactive compounds and PROTACs. It is a critical raw material for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and academic research institutions focused on creating next-generation therapeutics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of complex peptides containing brominated aromatic residues.
• Medicinal Chemistry & Drug Discovery: A key intermediate for constructing peptide-based drug candidates, enzyme inhibitors, and receptor ligands.
• PROTAC (Proteolysis Targeting Chimera) Development: Used to synthesize the linker or warhead components that connect the E3 ligase ligand to the target protein binder.
• Chemical Biology Probes: Incorporation into peptides for studying protein-protein interactions, cellular signaling, and target engagement.
• Process Chemistry & API Development: Serves as a chiral synthon in the scalable manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Enables the study of peptide structure-activity relationships (SAR) and the development of novel biomaterials.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(2-Bromo-Phenyl)-Propionic Acid
CAS No.	507472-17-5
Molecular Formula	C24H20BrNO4
Molecular Weight	466.33 g/mol
Synonyms	Fmoc-3-Amino-3-(2-bromophenyl)propanoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-bromophenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-bromophenyl)-L-β-homoalanine; Fmoc-2-Br-Phe(3-COOH)-OH; Fmoc-L-β-homo-2-bromophenylalanine; N-α-Fmoc-3-amino-3-(2-bromophenyl)propionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(2-Bromo-Phenyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.