Description

Fmoc-(S)-3-Amino-3-(3-Chloro-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the incorporation of a chlorinated phenylalanine analog into target sequences. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic agents, including enzyme inhibitors and receptor ligands.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of custom peptides and peptide libraries.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of novel drug candidates, particularly in oncology and metabolic disease research.
• Peptidomimetic Design: Used to create stable peptide analogs with enhanced bioavailability and receptor specificity by introducing a chlorinated aromatic side chain.
• Bioconjugation & Probe Development: Facilitates the site-specific labeling of peptides and proteins for diagnostic and biochemical assay applications.
• Academic & Industrial Research: Essential for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(3-Chloro-Phenyl)-Propionic Acid
CAS No.	507472-16-4
Molecular Formula	C24H20ClNO4
Molecular Weight	421.87 g/mol
Synonyms	Fmoc-3-Amino-3-(3-chlorophenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(3-chlorophenyl)propanoic acid; Fmoc-(S)-3-Amino-3-(3-Cl-Ph)-Prop-OH; Fmoc-3-(3-Chlorophenyl)-β-alanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chlorophenyl)propanoic acid; Fmoc-3-(3-Chloro-phenyl)-β-homoalanine; Fmoc-3-Amino-3-(3-chloro-phenyl)-propionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(3-Chloro-Phenyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.