Description

Fmoc-(S)-3-Amino-3-(2-Naphthyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a bulky 2-naphthyl side chain and an Fmoc-protected amine group. This compound is essential for the solid-phase peptide synthesis (SPPS) of complex peptides, where it introduces structural rigidity and aromatic character to influence folding, stability, and biological activity. It is a critical building block for pharmaceutical researchers and fine chemical manufacturers developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptide sequences in drug discovery.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of novel peptide-based drugs and APIs.
• Bioconjugation & Probe Development: Used to incorporate a hydrophobic, fluorescent naphthyl moiety into peptides for labeling, imaging, and diagnostic applications.
• Structure-Activity Relationship (SAR) Studies: Employed to study the effect of bulky aromatic residues on peptide conformation, receptor binding, and biological function.
• Peptidomimetics & Constrained Peptides: Integral for creating peptide analogs with enhanced metabolic stability and bioavailability.
• Biochemical Research: Used as a specialty reagent in academic and industrial labs for protein engineering and biochemical assay development.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(2-Naphthyl)-Propionic Acid
CAS No.	507472-11-9
Molecular Formula	C28H23NO4
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-3-(2-Naphthyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-naphthyl)-L-alanine; Fmoc-2-Nal-OH; Fmoc-3-(2-Naphthyl)alanine; N-α-Fmoc-3-(2-naphthyl)-L-alanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-2-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(2-Naphthyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (nitrogen or argon) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.