Description

2-Propen-1-One, 2-Fluoro-1-(4-Nitrophenyl)- (9Ci) is a specialized fluorinated α,β-unsaturated ketone building block, valued for its unique reactivity profile conferred by the electron-withdrawing nitro and fluoro substituents. This compound is essential for advanced organic synthesis, particularly in constructing complex molecular architectures for pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical and life sciences industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition or requiring fluorinated motifs for metabolic stability.
• Agrochemical Research: Used in the synthesis of advanced herbicide and pesticide candidates, leveraging its reactivity for creating heterocyclic systems.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored optical or electronic properties.
• Chemical Biology Probe Development: Employed in the synthesis of activity-based probes (ABPs) or fluorescent tags due to its electrophilic enone functionality.
• Academic & Industrial R&D: A valuable reagent for methodology development in organic chemistry, particularly in studies involving Michael additions or cycloaddition reactions.

Basic Information

Product Name	2-Propen-1-One, 2-Fluoro-1-(4-Nitrophenyl)- (9Ci)
CAS No.	506437-42-9
Molecular Formula	C9H6FNO3
Molecular Weight	195.15 g/mol
Synonyms	2-Fluoro-1-(4-nitrophenyl)prop-2-en-1-one; 1-(4-Nitrophenyl)-2-fluoroprop-2-en-1-one; 2-Fluoro-1-(4-nitrophenyl)-2-propen-1-one; (2-Fluoroethenyl)(4-nitrophenyl)methanone; 4-Nitro-2-fluorochalcone; 4-Nitrophenyl 2-fluorovinyl ketone; 506437-42-9
EINECS	Contact for details

Quality Control

Our production of 2-Propen-1-One, 2-Fluoro-1-(4-Nitrophenyl)- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research applications. All materials are fully characterized, and a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP-compliant documentation for advanced development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.