Description

(R)-Difluorphos(Tm) CAS NO 503538-70-3 is a high-value, chiral phosphine ligand widely used in asymmetric catalysis. Its significance lies in enabling highly enantioselective transformations, crucial for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component in enantioselective C-C and C-X bond-forming cross-coupling reactions.
• Critical for the synthesis of chiral active pharmaceutical ingredients (APIs) and agrochemicals.
• Used in academic and industrial research for developing new catalytic methodologies.
• Facilitates the production of enantiomerically pure flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(R)-Difluorphos(Tm)
CAS No.	503538-70-3
Molecular Formula	C31H21F2P
Molecular Weight	462.47 g/mol
Synonyms	(R)-Difluorphos; (R)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-bis(trifluoromethyl)phenyl)phosphine]; (R)-5,5'-Bis[bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-2,2'-dimethoxy-1,1'-biphenyl; (R)-DTBM-SEGPHOS; (R)-Xyl-DTBM-SEGPHOS; (R)-Bis[3,5-bis(trifluoromethyl)phenyl]-[6-(diphenylphosphino)-2-methoxy-1-biphenylyl]phosphine; (R)-[6-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-2-methoxy-3-biphenylyl]bis[3,5-bis(trifluoromethyl)phenyl]phosphine
EINECS	Contact for details

Quality Control

Our (R)-Difluorphos(Tm) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with every shipment, supporting cGMP and ISO standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.