Description

{4-[4-(Trifluoromethoxy)Phenyl]Phenyl}Boronic Acid is a high-value, functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring a trifluoromethoxy-substituted biphenyl core, makes it an essential reagent for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and OFETs, due to its electron-deficient aromatic system.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the creation of molecular probes and sensors for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CROs/CMOs serving the global life sciences market.

Basic Information

Product Name	{4-[4-(Trifluoromethoxy)Phenyl]Phenyl}Boronic Acid
CAS No.	501944-50-9
Molecular Formula	C13H10BF3O3
Molecular Weight	282.03 g/mol
Synonyms	[4'-(Trifluoromethoxy)[1,1'-biphenyl]-4-yl]boronic acid; 4-(4-Trifluoromethoxyphenyl)phenylboronic acid; (4'-(Trifluoromethoxy)biphenyl-4-yl)boronic acid; B-[4-[4-(Trifluoromethoxy)phenyl]phenyl]boronic acid; 4-(Trifluoromethoxy)[1,1'-biphenyl]-4-boronic acid
EINECS	Contact for details

Quality Control

Our {4-[4-(Trifluoromethoxy)Phenyl]Phenyl}Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect reactivity and stability. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.