Description

1,3-Benzodioxole-5-Carboxamide,n-(1S,2R,4R)-7-Azabicyclo[2.2.1]Hept-2-Yl- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders. It is primarily utilized by pharmaceutical R&D departments and contract manufacturing organizations (CMOs) engaged in the development of novel therapeutic agents.

Application

• Key Intermediate in Neurological Drug Synthesis: Serves as a crucial building block for the production of investigational and approved drugs targeting specific receptor pathways.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing of complex, chirally pure APIs.
• Contract Manufacturing: Supplied to CMOs and CDMOs producing APIs under cGMP guidelines for clinical trials and commercial supply.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1,3-Benzodioxole-5-Carboxamide,n-(1S,2R,4R)-7-Azabicyclo[2.2.1]Hept-2-Yl-
CAS No.	501893-07-8
Molecular Formula	C14H16N2O3
Molecular Weight	260.29 g/mol
Synonyms	(1S,2R,4R)-N-(Benzo[d][1,3]dioxol-5-yl)-7-azabicyclo[2.2.1]heptane-2-carboxamide; (1S,2R,4R)-2-[(1,3-Benzodioxol-5-ylcarbonyl)amino]-7-azabicyclo[2.2.1]heptane; 7-Azabicyclo[2.2.1]heptane-2-carboxamide, N-1,3-benzodioxol-5-yl-, (1S,2R,4R)-; 501893-07-8; (1S,2R,4R)-N-(1,3-Benzodioxol-5-yl)-7-azabicyclo[2.2.1]heptane-2-carboxamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, and chiral analysis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and commercial projects with material produced under GMP-like conditions as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.