Description

(S)-Hydroxy Iloperidone is a key chiral intermediate and a major active metabolite of the atypical antipsychotic drug Iloperidone. This high-purity compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for analytical reference standards and process development.

Application

• Primary use as a pharmaceutical reference standard for analytical method development and validation.
• Critical metabolite standard in pharmacokinetic (PK) and bioequivalence studies for Iloperidone.
• Key chiral building block in the research-scale synthesis of novel antipsychotic compounds.
• Used in impurity profiling and stability studies of Iloperidone API and finished dosage forms.
• Essential material for in-vitro and in-vivo metabolic pathway research.
• Supports regulatory filings (e.g., FDA, EMA) requiring characterization of major human metabolites.

Basic Information

Product Name	(S)-Hydroxy Iloperidone
CAS No.	501373-88-2
Molecular Formula	C24H27FN2O4
Molecular Weight	426.48 g/mol
Synonyms	1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethan-1-ol (S)-enantiomer; (S)-HPIP; Iloperidone Metabolite P95; (S)-Hydroxy Iloperidone Metabolite; (S)-4′-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]propoxy]-3′-methoxyacetophenone reduced alcohol; (S)-α-Hydroxy Iloperidone
EINECS	Contact for details

Quality Control

Our (S)-Hydroxy Iloperidone is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and mass spectrometry for structural confirmation, and stringent control of related substances. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.