Description

Fmoc-(S)-3-Amino-3-(3,5-Dimethoxy-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the solid-phase synthesis of complex peptides, enabling the incorporation of a constrained, aromatic side chain with specific stereochemistry. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require precise molecular control to create novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, used to introduce the (S)-3-amino-3-(3,5-dimethoxyphenyl)propionic acid moiety into peptide chains.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to create constrained peptide analogs and peptidomimetics with enhanced metabolic stability and binding affinity for drug discovery programs.
• Bioconjugation and Probe Development: Utilized in the synthesis of labeled peptides or peptide-conjugates for diagnostic, imaging, and biochemical research applications.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide-like compounds for high-throughput screening.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(3,5-Dimethoxy-Phenyl)-Propionic Acid
CAS No.	501015-38-9
Molecular Formula	C26H25NO7
Molecular Weight	463.48 g/mol
Synonyms	Fmoc-Ampa(3,5-OMe)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(3,5-dimethoxyphenyl)propanoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,5-dimethoxyphenyl)propanoic acid; Fmoc-3-Amino-3-(3,5-dimethoxyphenyl)propionic acid; Fmoc-(S)-3-Amino-3-(3,5-dimethoxybenzyl)-propionic Acid; Nα-Fmoc-3-amino-3-(3,5-dimethoxyphenyl)propionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(3,5-Dimethoxy-Phenyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.