Description

Fmoc-(S)-3-Amino-3-(2,3-Dimethoxy-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical chiral building block, enabling the precise incorporation of a constrained, aromatic side chain into peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical biology probes. Its structural features make it valuable for creating molecules with specific conformational and binding properties.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a direct reagent for automated and manual peptide assembly, particularly for introducing sterically hindered or conformationally restricted residues.
• Peptidomimetic Drug Discovery: Serves as a key scaffold in the design and synthesis of peptide-like molecules with enhanced metabolic stability, bioavailability, and target affinity for potential therapeutic applications.
• Chemical Biology & Proteomics: Used to synthesize custom peptide substrates, inhibitors, or activity-based probes for studying enzyme function, protein-protein interactions, and cellular signaling pathways.
• Pharmaceutical Intermediate: Acts as a chiral intermediate in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) targeting neurological disorders, oncology, and metabolic diseases.
• Material Science & Specialty Polymers: Incorporated into novel polymeric materials to impart specific chiral, optical, or self-assembly properties for advanced material applications.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(2,3-Dimethoxy-Phenyl)-Propionic Acid
CAS No.	501015-36-7
Molecular Formula	C26H25NO6
Molecular Weight	447.48 g/mol
Synonyms	(S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,3-dimethoxyphenyl)propanoic acid; Fmoc-3-Amino-3-(2,3-dimethoxyphenyl)propionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2,3-dimethoxyphenyl)-L-β-homoalanine; Fmoc-L-3-(2,3-Dimethoxyphenyl)alanine derivative; Fmoc-(2,3-Dimethoxy-DL-phenylalanine) analog; N-Fmoc-3-amino-3-(2,3-dimethoxy-phenyl)propanoic acid; (S)-3-(2,3-Dimethoxyphenyl)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(2,3-Dimethoxy-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.