Description

Fmoc-(S)-3-Amino-3-(2-Hydroxy-Phenyl)-Propionic Acid is a protected amino acid derivative featuring an Fmoc group and a phenolic hydroxyl group, making it a versatile chiral building block for solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled synthesis of complex peptides and peptidomimetics that incorporate tyrosine-like phenolic moieties with precise stereochemistry. This compound is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing novel therapeutic peptides, and for fine chemical synthesis requiring high-purity, custom amino acid derivatives.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of peptides containing non-natural phenolic amino acid residues.
• Pharmaceutical Intermediate: A key chiral precursor in the research and development of peptide-based drugs and bioactive compounds.
• Peptidomimetic Design: Used to incorporate rigid, aromatic side chains into peptide backbones to enhance stability, binding affinity, and metabolic resistance.
• Chemical Biology Probes: Synthesis of labeled peptides or affinity tags for studying protein-protein interactions and enzyme activity.
• Asymmetric Synthesis: Serves as a chiral pool synthon for the preparation of more complex, enantiomerically pure molecules in medicinal chemistry.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(2-Hydroxy-Phenyl)-Propionic Acid
CAS No.	501015-31-2
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(2-hydroxyphenyl)propanoic acid; Fmoc-3-Amino-3-(2-hydroxyphenyl)propionic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-hydroxyphenyl)propanoic acid; Fmoc-Amp(2-OH)-OH; Fmoc-3-Amino-3-(2-hydroxybenzyl)propionic acid; N-Fmoc-3-amino-3-(2-hydroxyphenyl)propionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(2-Hydroxy-Phenyl)-Propionic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and custom purity grades (e.g., >98%, >99%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.