Description

Boc-(R)-3-Amino-3-(3-Thienyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine group and a thiophene side chain. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural and electronic properties into target molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel active pharmaceutical ingredients (APIs), especially in areas targeting central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and small molecule drugs.
• Peptidomimetic Synthesis: Used to incorporate a thienylalanine analog into peptide backbones, modifying stability, bioavailability, and receptor binding affinity.
• Protease Inhibitor Development: Serves as a core component in the design of inhibitors for various enzymes, including proteases involved in viral and metabolic pathways.
• Chemical Biology & Probe Design: Employed in creating labeled or tagged molecular probes for studying protein-protein interactions and enzyme mechanisms.
• Academic & Industrial Research: A valuable reagent for synthetic organic chemistry research focused on asymmetric synthesis and heterocyclic chemistry.
• Custom Peptide Services: Supplied to CROs and CDMOs for the custom synthesis of complex peptide sequences for clients.

Basic Information

Product Name	Boc-(R)-3-Amino-3-(3-Thienyl)-Propionic Acid
CAS No.	500788-99-8
Molecular Formula	C₁₂H₁₇NO₄S
Molecular Weight	271.33 g/mol
Synonyms	(R)-3-((tert-Butoxycarbonyl)amino)-3-(thiophen-3-yl)propanoic acid; (R)-3-(Boc-amino)-3-(3-thienyl)propionic acid; Boc-β-(3-Thienyl)-D-homoalanine; tert-Butyl (R)-3-(3-thienyl)-3-aminopropionate N-Boc derivative; N-Boc-3-(3-thienyl)-D-alanine; Boc-D-3-Thienylalanine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(thiophen-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Boc-(R)-3-Amino-3-(3-Thienyl)-Propionic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥98%), and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.