Description

4-(4-Fluoro-Phenyl)-3-Oxo-Butyric Acid Methyl Ester is a high-purity fluorinated keto-ester building block of significant importance in advanced organic synthesis. This compound serves as a versatile intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is essential for research and development chemists and process engineers working on active pharmaceutical ingredients (APIs), fine chemicals, and novel material science applications where the introduction of a fluorine atom and a β-keto ester moiety is required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including potential kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine substituent enhances biological activity and environmental stability.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Chemical Research & Development: Serves as a fundamental building block for Knorr pyrrole synthesis, Claisen condensations, and other carbon-carbon bond-forming reactions in academic and industrial R&D labs.
• Fluorine Chemistry Studies: A valuable substrate for investigating the effects of fluorine substitution on reaction pathways and physicochemical properties in medicinal and synthetic chemistry.

Basic Information

Product Name	4-(4-Fluoro-Phenyl)-3-Oxo-Butyric Acid Methyl Ester
CAS No.	500366-84-7
Molecular Formula	C11H11FO3
Molecular Weight	210.20 g/mol
Synonyms	Methyl 4-(4-fluorophenyl)-3-oxobutanoate; 3-Oxo-4-(4-fluorophenyl)butyric acid methyl ester; 4-(4-Fluorophenyl)-3-oxobutanoic acid methyl ester; Methyl 3-oxo-4-(4-fluorophenyl)butyrate; 4-Fluorophenylacetone carboxylic acid methyl ester; 4-(p-Fluorophenyl)-3-oxobutyric acid methyl ester; Butanoic acid, 4-(4-fluorophenyl)-3-oxo-, methyl ester
EINECS	Contact for details

Quality Control

Our 4-(4-Fluoro-Phenyl)-3-Oxo-Butyric Acid Methyl Ester is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.