Description

Hemoglobin Philly is a naturally occurring variant of human hemoglobin, characterized by a specific point mutation that provides a unique model for biochemical and clinical research. This compound is essential for studying the structure-function relationships of hemoglobin, oxygen transport anomalies, and the molecular basis of certain hemoglobinopathies. It serves as a critical reference standard and research reagent for pharmaceutical R&D, clinical diagnostics, and academic institutions focused on hematology and genetic disorders.

Application

• Biochemical Research: Used as a model protein to investigate the effects of specific amino acid substitutions on hemoglobin stability, oxygen affinity, and allosteric regulation.
• Clinical Diagnostics Development: Serves as a reference material in the development and calibration of diagnostic assays for detecting and characterizing rare hemoglobin variants.
• Pharmaceutical R&D: Employed in target validation and screening studies for therapeutic agents aimed at modulating hemoglobin function or treating related disorders.
• Academic Studies: A key tool for teaching and advanced research in university laboratories focusing on protein chemistry, molecular biology, and genetic diseases.
• Biotechnology: Potential use in the engineering of hemoglobin-based oxygen carriers (HBOCs) or biosensors.

Basic Information

Product Name	Hemoglobin Philly
CAS No.	59979-44-1
Molecular Formula	C2952H4664N812O832S40Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Philly; Hemoglobin β-chain mutant (Tyrosine to Phenylalanine); Hemoglobin variant Philly; β35(C1) Tyr→Phe Hemoglobin; Unstable Hemoglobin Philly; Hb β35 Tyr→Phe; Hemoglobin (β35 Tyr→Phe)
EINECS	Contact for details

Quality Control

Our Hemoglobin Philly is produced and handled under stringent quality protocols. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), spectral properties, and functional assays is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. The product should be handled under appropriate laboratory conditions to maintain its native state and prevent denaturation.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR / UV-Vis)	Conforms to standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Methemoglobin Content	< 5%
Oxygen Binding Capacity	Assessed functionally
Solubility	Clear solution in buffer
Endotoxin Level	< 1.0 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.