Description

Crotoxin, A-Subunit is a specific, high-purity protein component isolated from the venom of the South American rattlesnake (*Crotalus durissus terrificus*). This compound is of significant interest for advanced biochemical and pharmacological research due to its role as the non-toxic, phospholipase A2-inactive subunit of the potent neurotoxin complex, crotoxin. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in neurobiology, toxin-antitoxin interaction studies, and the development of novel therapeutic platforms.

Application

• Biochemical Research: Used as a critical reagent for studying the structure, function, and mechanism of action of phospholipase A2 neurotoxins.
• Neuroscience Studies: Essential for investigating synaptic transmission, neuromuscular junction blockade, and neurotoxic pathways.
• Antivenom Development: Serves as a key antigen or reference standard in the research and quality control of antivenom sera.
• Drug Discovery Platform: Investigated for its potential in targeted drug delivery systems and as a molecular scaffold for designing novel biotherapeutics.
• Toxicology & Safety Assessment: Employed in studies to understand toxin metabolism, neutralization, and for comparative toxicity profiling.
• Academic & Pharmaceutical R&D: A vital tool for basic scientific discovery and applied research in major life science and pharmaceutical laboratories worldwide.

Basic Information

Product Name	Crotoxin, A-Subunit
CAS No.	59979-26-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Crotapotin; Crotoxin Acidic Subunit; Crotoxin Component A; Crotoxin A Chain; Crotalus Toxin A Subunit; Phospholipase A2 Inhibitory Subunit of Crotoxin; Crotactin
EINECS	Contact for details

Quality Control

Our Crotoxin, A-Subunit is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, electrophoresis, and spectroscopic methods. A Certificate of Analysis (COA) detailing purity, identity, and specific activity is provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (UV)	≥ 90%
Biological Activity	Confirmed (Inhibition of Crotoxin complex toxicity)
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.