Description

Sulindac Sulfide Acyl-β-D-Glucuronide is a key metabolite and reference standard of the non-steroidal anti-inflammatory drug (NSAID) sulindac sulfide. This compound is critical for pharmaceutical research and development, particularly in studies of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in advanced drug discovery and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the qualitative and quantitative analysis of sulindac and its metabolites in drug substance and finished product testing.
• Metabolite Research: Used in in vitro and in vivo studies to investigate the metabolic pathways, bioavailability, and clearance mechanisms of sulindac sulfide.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for pharmacokinetic and toxicokinetic studies.
• Impurity Profiling: Acts as a known impurity or degradation product standard to monitor the stability and purity of sulindac-based pharmaceutical formulations.
• Clinical Research: Employed in studies to understand the correlation between metabolite levels and therapeutic efficacy or safety profiles.
• Regulatory Submissions: Provides critical data for regulatory filings (e.g., with FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolic fate.

Basic Information

Product Name	Sulindac Sulfide Acyl-β-D-Glucuronide
CAS No.	59973-78-3
Molecular Formula	C25H27NO9S
Molecular Weight	517.55 g/mol
Synonyms	Sulindac Sulfide Glucuronide; (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid β-D-Glucopyranosiduronic acid; 1-[[(1Z)-5-Fluoro-2-methyl-3-[(4-methylsulfinyl)benzylidene]-1H-inden-1-yl]acetyl]glucuronic acid; Sulindac sulfide β-D-glucuronide; Acyl glucuronide of sulindac sulfide
EINECS	Contact for details

Quality Control

Our Sulindac Sulfide Acyl-β-D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry guidelines to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.