Description

8-Hydroxycarteolol is a key pharmaceutical intermediate and metabolite of the β-blocker carteolol. This compound matters for its critical role in drug metabolism studies, pharmacokinetic research, and the development of analytical reference standards. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) and high-purity fine chemicals.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of carteolol and its metabolites in drug substance and finished product analysis.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, bioavailability, and excretion profiles of carteolol hydrochloride.
• Analytical Method Development: Serves as a critical standard for developing and validating HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Impurity Profiling: Employed to identify, monitor, and control related substance impurities during the synthesis and purification of carteolol API.
• Preclinical & Clinical Studies: Utilized in pharmacological and toxicological research to understand the safety and efficacy profile of carteolol's metabolites.
• Chemical Synthesis: Acts as a building block or precursor for the synthesis of novel carteolol analogs and derivatives for research purposes.

Basic Information

Item	Details
Product Name	8-Hydroxycarteolol
CAS No.	59826-22-1
Molecular Formula	C16H24N2O4
Molecular Weight	308.37 g/mol
Synonyms	8-Hydroxycarteolol; 5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone; 8-Hydroxy Carteolol; Carteolol Metabolite; Carteolol Impurity; OPC-1426 Metabolite; (±)-8-Hydroxycarteolol; 1-(tert-Butylamino)-3-[(8-hydroxy-3,4-dihydro-2H-1-benzopyran-5-yl)oxy]-2-propanol
EINECS	Contact for details

Quality Control

Our 8-Hydroxycarteolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.