Description

Thiamine Thiazolone Pyrophosphate is a synthetic, biologically active derivative of vitamin B1 (thiamine). This compound is a crucial coenzyme precursor and research chemical, valued for its role in studying thiamine-dependent enzymatic processes. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers involved in biochemical research, metabolic studies, and high-purity reference standard production.

Application

• Biochemical Research: Used as a key intermediate or reference standard in the study of thiamine pyrophosphate (TPP)-dependent enzymes, such as transketolase and pyruvate dehydrogenase.
• Pharmaceutical Development: Serves as a critical starting material or analytical standard in the synthesis and quality control of novel thiamine-based therapeutics and prodrugs.
• Metabolic Pathway Analysis: Employed in laboratory settings to investigate cellular metabolism, energy production, and the biochemical mechanisms of thiamine deficiency.
• Enzyme Kinetics Studies: Acts as a substrate or inhibitor analog in enzymatic assays to determine kinetic parameters and elucidate reaction mechanisms.
• Diagnostic Reagent Manufacturing: Incorporated into the formulation of specialized diagnostic kits and reagents for clinical and research laboratories.
• High-Purity Reference Standard: Supplied as a certified reference material (CRM) for analytical method development, validation, and quality assurance in regulatory-compliant environments.

Basic Information

Product Name	Thiamine Thiazolone Pyrophosphate
CAS No.	59733-97-0
Molecular Formula	C12H18N4O7P2S
Molecular Weight	424.30 g/mol
Synonyms	Thiamine Thiazolone Diphosphate; Thiamine Thiazolone Pyrophosphate Ester; Thiamine Monophosphate Thiazolone Derivative; TTP Analog; Vitamin B1 Thiazolone Pyrophosphate; 4-Amino-2-methyl-5-pyrimidinylmethyl 4-Methyl-5-(2-phosphonooxyethyl)-3-[(phosphonooxy)methyl]thiazol-3-ium-2-yl Ketone; Thiamine Pyrophosphate Thiazolone
EINECS	Contact for details

Quality Control

Our Thiamine Thiazolone Pyrophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and moisture content. We provide Certificates of Analysis (COA) with detailed specifications for traceability and compliance. Our quality commitment ensures the material is suitable for demanding applications in pharmaceutical research and as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.