Description

Fexinidazole CAS NO 59729-37-2 is a nitroimidazole-based antiprotozoal agent. This compound is of significant commercial and therapeutic interest as the first all-oral treatment approved for human African trypanosomiasis (sleeping sickness). It is primarily required by pharmaceutical research organizations, API manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the development of antiparasitic medications.

Application

• Active Pharmaceutical Ingredient (API) for the treatment of human African trypanosomiasis (HAT), stage 1 and 2.
• Research and Development of novel antiparasitic and antimicrobial therapeutics.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Preclinical and Clinical Studies for evaluating efficacy and safety profiles.
• Formulation Development for creating stable and bioavailable oral dosage forms.
• Chemical Intermediate for the synthesis of related nitroimidazole derivatives.

Basic Information

Product Name	Fexinidazole
CAS No.	59729-37-2
Molecular Formula	C12H14N4O4S
Molecular Weight	310.33 g/mol
Synonyms	Fexinidazole; 1-Methyl-2-[(4-methylthio)phenoxy]methyl-5-nitroimidazole; HAT-1; Fexinidazole (USAN); Fexinidazolum; WHO 10172; DB13183; Fexinidazole [USAN:INN]
EINECS	Contact for details

Quality Control

Our Fexinidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength, meeting the stringent requirements for pharmaceutical intermediates and APIs. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.