Description

10-Chloro Carbamazepine is a key halogenated derivative of the anticonvulsant drug carbamazepine, serving as a critical advanced pharmaceutical intermediate. This compound is essential for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and exploring new therapeutic pathways. It is primarily utilized in the pharmaceutical and fine chemical sectors for the synthesis of next-generation neuroactive compounds and for analytical reference standards.

Application

• Pharmaceutical Intermediate: A crucial building block in the research and synthesis of novel carbamazepine analogs and other central nervous system (CNS) active drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in the development and scale-up processes for new potential therapeutic agents.
• Metabolite Studies: Serves as a reference standard or synthetic target for studying the metabolism and pharmacokinetics of carbamazepine and related compounds.
• Chemical Research: Employed in academic and industrial R&D for structure-activity relationship (SAR) studies and medicinal chemistry programs.
• Analytical Standard: Used as a high-purity certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	10-Chloro Carbamazepine
CAS No.	59690-92-5
Molecular Formula	C15H11ClN2O
Molecular Weight	270.71 g/mol
Synonyms	10-Chloro-5H-dibenzo[b,f]azepine-5-carboxamide; 10-Chloro-5H-dibenz[b,f]azepine-5-carboxamide; 10-Chloro-CBZ; 10-Cl-Carbamazepine; 10-Chloro Carbamazepine Impurity; Carbamazepine Impurity G (Chloro Derivative); 10-Chloro-5-carbamoyl-5H-dibenzo[b,f]azepine
EINECS	Contact for details

Quality Control

Our 10-Chloro Carbamazepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.