Description

(4As)-2,3,4A,8,9,10,10Aβ,10B-Octahydro-10α-Hydroxy-4Aα,8β,10Bα-Trimethyl-1H-Naphtho[2,1-B]Pyran-1-One is a complex, high-purity synthetic intermediate with a defined stereochemistry, crucial for advanced organic synthesis. Its value lies in its role as a key chiral building block for constructing intricate molecular architectures found in pharmaceuticals and specialty chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex polycyclic frameworks.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry impacts biological activity.
• Fine Chemical Production: Acts as a building block for creating specialty chemicals, flavors, fragrances, and advanced materials with specific three-dimensional structures.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, including catalysis, total synthesis, and stereoselective transformation research.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production for target molecules.

Basic Information

Item	Details
Product Name	(4As)-2,3,4A,8,9,10,10Aβ,10B-Octahydro-10α-Hydroxy-4Aα,8β,10Bα-Trimethyl-1H-Naphtho[2,1-B]Pyran-1-One
CAS No.	59684-36-5
Molecular Formula	C₁₈H₂₈O₃
Molecular Weight	292.41 g/mol
Synonyms	10α-Hydroxy-4aα,8β,10bα-trimethyl-1-oxo-1,2,3,4,4a,8,9,10,10aβ,10b-decahydronaphtho[2,1-b]pyran; 10α-Hydroxy-4aα,8β,10bα-trimethyl-1-oxo-1,2,3,4,4a,8,9,10,10aβ,10b-decahydronaphtho[2,1-b]pyran; (4aR,8S,10aR,10bS)-10-Hydroxy-4a,8,10b-trimethyl-1-oxo-1,2,3,4,4a,8,9,10,10a,10b-decahydronaphtho[2,1-b]pyran; Naphtho[2,1-b]pyran-1-one derivative; Chiral decahydronaphthopyranone intermediate; Stereoisomeric lactone building block.
EINECS	Contact for details

Quality Control

Our production of (4As)-2,3,4A,8,9,10,10Aβ,10B-Octahydro-10α-Hydroxy-4Aα,8β,10Bα-Trimethyl-1H-Naphtho[2,1-B]Pyran-1-One adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and GC/MS for solvent residue analysis, to ensure it meets precise customer specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.