Description

Boc-L-Lys(Palm)-OH is a protected amino acid derivative where the lysine side chain is modified with a palmitoyl group and the α-amino group is protected with a tert-butyloxycarbonyl (Boc) moiety. This specialized building block is critical for the controlled synthesis of lipopeptides and modified peptides, enabling the introduction of hydrophobic lipid chains to alter biological activity and physicochemical properties. It is primarily utilized by researchers and manufacturers in pharmaceutical development, peptide synthesis, and biochemical research for creating novel therapeutic agents and probes.

Application

• Lipopeptide Synthesis: A key intermediate for the solid-phase or solution-phase synthesis of lipopeptides, which are important for vaccine adjuvants and antimicrobial agents.
• Pharmaceutical Research: Used in the development of peptide-based drugs where lipid conjugation (palmitoylation) is employed to enhance membrane permeability, stability, or targeting.
• Bioconjugation & Probe Development: Serves as a building block for creating fluorescently labeled or otherwise tagged lipidated peptides for cellular imaging and mechanism-of-action studies.
• Biochemical Tool Compound Production: Essential for manufacturing research-grade peptides that mimic naturally occurring lipidated proteins, such as those involved in signal transduction.
• Cosmeceutical Ingredient Development: Investigated for use in the synthesis of bioactive peptides for skincare applications, where lipid modification can improve skin penetration.

Basic Information

Product Name	Boc-L-Lys(Palm)-OH
CAS No.	59515-45-6
Molecular Formula	C27H52N2O5
Molecular Weight	484.72 g/mol
Synonyms	N6-Palmitoyl-N2-[(tert-butoxy)carbonyl]-L-lysine; Boc-Lys(Palmitoyl)-OH; Nα-Boc-Nε-palmitoyl-L-lysine; (2S)-6-(Hexadecanoylamino)-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid; Boc-Lys(Palm)-OH; tert-Butyloxycarbonyl-Nε-palmitoyl-L-lysine; N-[(1,1-Dimethylethoxy)carbonyl]-N6-palmitoyl-L-lysine; Boc-Nε-palmitoyl-L-lysine
EINECS	Contact for details

Quality Control

Our Boc-L-Lys(Palm)-OH is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.