Description

n-[(Benzyloxy)Carbonyl]-D-Glutamic Acid 1-(4-Nitrophenyl)5-Benzyl Ester is a high-purity, protected amino acid derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group protection in peptide and small molecule development. It is primarily utilized in pharmaceutical R&D for the synthesis of complex active pharmaceutical ingredients (APIs), diagnostic agents, and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and complex organic molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the D-glutamic acid moiety and protecting groups are required.
• Protecting Group Strategy: The benzyloxycarbonyl (Cbz) and benzyl ester groups allow for orthogonal deprotection in complex synthetic routes.
• Research & Development: Serves as a standard or custom building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Bioconjugation: Potential use in creating labeled compounds or conjugates for diagnostic applications, leveraging the reactive ester and protected acid groups.
• Chemical Biology Probes: Used in the development of enzyme inhibitors or activity-based probes targeting glutamic acid-specific processes.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-D-Glutamic Acid 1-(4-Nitrophenyl)5-Benzyl Ester
CAS No.	59486-72-5
Molecular Formula	C26H24N2O8
Molecular Weight	492.48 g/mol
Synonyms	D-Glutamic Acid, N-[(benzyloxy)carbonyl]-, 1-(4-nitrophenyl) 5-benzyl ester; (R)-2-(((Benzyloxy)carbonyl)amino)pentanedioic acid 1-(4-nitrophenyl) 5-benzyl ester; N-Cbz-D-glutamic acid α-(4-nitrophenyl) ester γ-benzyl ester; Z-D-Glu(OBzl)-ONp; N-Carbobenzoxy-D-glutamic acid 1-(4-nitrophenyl) 5-benzyl ester; Nα-Cbz-D-glutamic acid 1-(4-nitrophenyl) 5-benzyl ester; CBZ-D-Glutamic Acid α-p-Nitrophenyl Ester γ-Benzyl Ester
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-D-Glutamic Acid 1-(4-Nitrophenyl)5-Benzyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.