Description

Midazolam 2-Oxide is a key pharmaceutical intermediate and a significant metabolite of the sedative-hypnotic agent Midazolam. This compound is essential for research and development in neuropharmacology, particularly in studies related to drug metabolism, pharmacokinetics, and the mechanism of action of benzodiazepines. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard suppliers, and academic institutions conducting advanced pharmacological research.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the analytical quantification of Midazolam and its metabolites in biological matrices.
• Metabolic Pathway Research: Critical for in-vitro and in-vivo studies investigating the biotransformation and metabolic fate of Midazolam.
• Impurity Profiling: Serves as a known impurity standard in the quality control and stability testing of Midazolam Active Pharmaceutical Ingredient (API) and finished drug products.
• Biochemical Research: Employed in studies exploring the structure-activity relationships (SAR) of benzodiazepine derivatives and their interaction with GABA-A receptors.
• Forensic & Clinical Toxicology: Used as an analytical standard in forensic labs and hospitals for the precise identification and measurement of Midazolam metabolites in toxicological screenings.

Basic Information

Product Name	Midazolam 2-Oxide
CAS No.	59468-86-9
Molecular Formula	C18H13ClFN3O2
Molecular Weight	357.77 g/mol
Synonyms	8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2-oxide; Midazolam N-Oxide; Midazolam Metabolite (2-Oxide); 1-Methyl-8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine 2-oxide; Ro 21-3981/002; U-32978E
EINECS	Contact for details

Quality Control

Our Midazolam 2-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every shipment to ensure full traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.