Description

Calcimycin Hemicalcium Salt is a specialized calcium complex of the potent ionophore antibiotic calcimycin (A23187). This compound is a critical biochemical tool for modulating intracellular calcium levels, enabling precise research into calcium-mediated signaling pathways. It is essential for researchers and manufacturers in pharmaceutical development, cell biology, and biochemical research, particularly for studying cellular processes like apoptosis, secretion, and immune response.

Application

• Biochemical Research: As a selective calcium ionophore to artificially increase intracellular Ca²⁺ concentration in cell culture and in vitro studies.
• Cell Signaling Studies: Investigation of calcium-dependent signal transduction pathways, enzyme activation, and gene expression.
• Pharmaceutical Screening: Used in assays to study the effects of potential drug candidates on calcium homeostasis and channel activity.
• Immunology Research: To stimulate lymphocyte proliferation and cytokine production in immunological assays.
• Apoptosis Research: Induction of programmed cell death for studying cancer biology and therapeutic mechanisms.
• Muscle Physiology Studies: Research into calcium's role in muscle contraction and cardiac function.
• Neuroscience: Studying the role of calcium in neurotransmitter release and neuronal excitability.

Basic Information

Product Name	Calcimycin Hemicalcium Salt
CAS No.	59450-89-4
Molecular Formula	C₂₉H₃₆CaN₂O₆
Molecular Weight	548.70 g/mol
Synonyms	Calcimycin Calcium Salt; Antibiotic A23187 Hemicalcium Salt; A23187 Hemicalcium Salt; Calcium Ionophore A23187 Hemicalcium Salt; 4-Bromo-A23187 Hemicalcium Salt; (2S,3S,5R,6S)-6-[(5S,6S)-6-[(2R,3S,5R)-5-Methyl-3,6-dihydro-2H-pyran-2-yl]-5-methyl-5,6-dihydro-2H-pyran-2-yl]-5-methyl-2-[(2R)-2-piperidinyl]-4-benzoxazolecarboxylic Acid Hemicalcium Salt
EINECS	Contact for details

Quality Control

Our Calcimycin Hemicalcium Salt is produced and tested under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances. We adhere to relevant quality guidelines suitable for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤1.0%
Biological Activity	Tested in standard calcium flux assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.