Description

Aminomethyldithiolano Phalloidin is a chemically modified derivative of the potent mycotoxin phalloidin, designed for advanced biochemical research applications. This derivative is particularly valued for its utility in creating targeted conjugates for cellular imaging and molecular probe development. It is an essential reagent for researchers in pharmacology, toxicology, and cell biology who require high-purity, well-characterized compounds for studying cytoskeletal dynamics and cellular uptake mechanisms. The product is supplied with full analytical documentation to ensure research integrity and reproducibility.

Application

• Fluorescent Probe Synthesis: Acts as a key intermediate for conjugating phalloidin with fluorophores (e.g., FITC, TRITC, Alexa Fluor dyes) to create highly specific F-actin staining reagents for confocal and super-resolution microscopy.
• Biochemical Research: Used in studies investigating the mechanism of action of phallotoxins, including their binding affinity to actin filaments and inhibition of depolymerization.
• Cytoskeleton Studies: Essential for developing tools to visualize and quantify filamentous actin (F-actin) in fixed and live cells, aiding research in cell motility, morphology, and division.
• Toxicology and Pharmacology: Serves as a reference standard or a precursor for producing labeled toxins used in uptake, trafficking, and cytotoxicity assays.
• Drug Discovery: Utilized in high-throughput screening assays to identify potential inhibitors or antagonists of phalloidin's interaction with actin.
• Diagnostic Development: Potential use in the development of diagnostic kits or assays for detecting amatoxin poisoning, leveraging its specific binding properties.

Basic Information

Product Name	Aminomethyldithiolano Phalloidin
CAS No.	148333-39-5
Molecular Formula	C36H51N7O11S2
Molecular Weight	821.96 g/mol
Synonyms	7-Aminomethyl-4,6-dihydroxy-2-mercapto-1,7-dithia-4,6-diaza-s-indacene; Phalloidin, 7-(aminomethyl)-4,6-dihydroxy-2-mercapto-1,7-dithia-4,6-diaza-s-indacene; Aminomethyl-DTP; DTP-amine; Phalloidin derivative, amino-functionalized; Aminomethyldithiaphalloidin; Thiol-reactive phalloidin derivative
EINECS	Contact for details

Quality Control

Every batch of Aminomethyldithiolano Phalloidin is manufactured and analyzed under strict quality systems. We employ advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), related substances, and physical characteristics is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.