Description

n-Desmethylmeptazinol is a key pharmaceutical intermediate and reference standard of significant importance in analytical chemistry and drug development. This compound is critical for ensuring the quality, safety, and efficacy of related pharmaceutical products through precise analytical testing. It is primarily utilized by research institutions, pharmaceutical manufacturers, and quality control laboratories involved in the synthesis and analysis of opioid analgesics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of meptazinol and related compounds in drug substances and finished products.
• Metabolite Studies: Serves as a critical standard in pharmacokinetic and metabolic pathway research for understanding drug disposition and biotransformation.
• Impurity Profiling: Essential for the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) manufacturing, supporting regulatory filings.
• Analytical Method Development: Employed in the development and validation of chromatographic methods (HPLC, LC-MS) for pharmaceutical quality control.
• Pharmacological Research: Used in preclinical studies to investigate the structure-activity relationships (SAR) of opioid receptor ligands.
• Forensic Analysis: Acts as a standard for the detection and confirmation of meptazinol and its metabolites in forensic toxicology.

Basic Information

Product Name	n-Desmethylmeptazinol
CAS No.	59263-75-1
Molecular Formula	C14H21NO
Molecular Weight	219.33 g/mol
Synonyms	1-(3-Ethyl-1-methylhexahydro-1H-azepin-3-yl)phenol; Desmethylmeptazinol; Nor-Meptazinol; Meptazinol Impurity; Meptazinol Metabolite; Opioid Analgesic Intermediate; WY-22811 Metabolite
EINECS	Contact for details

Quality Control

Our n-Desmethylmeptazinol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced techniques like HPLC and GC-MS. We support compliance with ICH guidelines for impurities and can provide materials aligned with pharmacopeial standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.