Description

2-Propen-1-One, 3-(Dimethylamino)-2-Fluoro-1-(4-Methylphenyl)-, (Z)- (9Ci) is a specialized fluorinated α,β-unsaturated ketone derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its molecular architecture, featuring a dimethylamino group and a fluorine atom on the α,β-unsaturated carbonyl system, makes it a critical building block for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the fluorine atom enhances biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Organic Synthesis Building Block: Employed in Michael addition reactions, cycloadditions, and other transformations to introduce the (Z)-configured fluorinated enone moiety into complex molecular frameworks.
• Fluorine Chemistry Studies: A valuable substrate for investigating the influence of fluorine substitution on reaction mechanisms and physicochemical properties in academic and industrial R&D.

Basic Information

Product Name	2-Propen-1-One, 3-(Dimethylamino)-2-Fluoro-1-(4-Methylphenyl)-, (Z)- (9Ci)
CAS No.	59160-27-9
Molecular Formula	C₁₂H₁₄FNO
Molecular Weight	207.24 g/mol
Synonyms	(Z)-3-(Dimethylamino)-2-fluoro-1-(4-methylphenyl)prop-2-en-1-one; 2-Fluoro-3-(dimethylamino)-1-(4-methylphenyl)-2-propen-1-one, (Z)-; 3-(Dimethylamino)-2-fluoro-1-(p-tolyl)-2-propen-1-one (Z)-; (Z)-3-(Dimethylamino)-2-fluoro-1-(p-tolyl)prop-2-en-1-one; (Z)-2-Fluoro-3-(dimethylamino)-1-(4-methylphenyl)-2-propen-1-one; 59160-27-9; (Z)-enone fluorinated derivative
EINECS	Contact for details

Quality Control

Our production of 2-Propen-1-One, 3-(Dimethylamino)-2-Fluoro-1-(4-Methylphenyl)-, (Z)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including HPLC for purity and isomer content, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent potential degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (Z-Isomer)	≥ 95.0% (by HPLC)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.