Description

Di(n-Succinimidyl) Adipate is a homobifunctional N-hydroxysuccinimide (NHS) ester crosslinker used for conjugating primary amines. This compound matters because it provides a reliable and efficient method for creating stable amide bonds between biomolecules, enabling the study of protein interactions and the development of diagnostic assays. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, proteomics, and antibody-drug conjugate (ADC) development.

Application

• Bioconjugation Reagent: For covalently linking proteins, peptides, or antibodies to other molecules, surfaces, or carriers.
• Proteomics Research: Used in crosslinking mass spectrometry (XL-MS) to study protein-protein interactions and complex structures.
• Immunoassay Development: Facilitates the labeling of antibodies with enzymes, fluorophores, or haptens for diagnostic test kits.
• Biomaterial Modification: Functionalizes polymers, nanoparticles, or solid supports with amine-containing bioactive ligands.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a cleavable or non-cleavable spacer in the synthesis of targeted therapeutics.
• Immobilization Chemistry: For attaching amine-containing biomolecules to activated chromatography resins or biosensor chips.

Basic Information

Product Name	Di(n-Succinimidyl) Adipate
CAS No.	59156-70-6
Molecular Formula	C16H20N2O8
Molecular Weight	368.34 g/mol
Synonyms	Disuccinimidyl Adipate; DSA; N,N'-Disuccinimidyl Adipate; Adipic Acid Bis(N-succinimidyl) Ester; Bis(N-succinimidyl) Adipate; Adipic Acid Di(N-succinimidyl) Ester; NSC 112192; N,N'-(Adipoyldioxy)disuccinimide
EINECS	Contact for details

Quality Control

Our Di(n-Succinimidyl) Adipate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.