Description

3-[(Aminoacetyl)Amino]-5-[[(2-Hydroxyethyl)Amino]Carbonyl]-2,4,6-Triiodobenzoic Acid is a high-purity, iodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. Its molecular structure, featuring a triiodinated benzene core with functionalized side chains, is critical for developing non-ionic, low-osmolar contrast agents with improved patient safety profiles. This compound is essential for pharmaceutical manufacturers and R&D facilities focused on diagnostic imaging, requiring a reliable and consistent supply of high-grade chemical building blocks.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of non-ionic X-ray contrast agents like Iopamidol and Ioversol.
• Diagnostic Imaging Research: Used in R&D for developing new generations of iodinated contrast media with enhanced safety and efficacy.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthesis processes for final drug substances.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Radiology Agent Development: Key material for formulating experimental contrast solutions for computed tomography (CT) and angiography.

Basic Information

Product Name	3-[(Aminoacetyl)Amino]-5-[[(2-Hydroxyethyl)Amino]Carbonyl]-2,4,6-Triiodobenzoic Acid
CAS No.	59017-39-9
Molecular Formula	C12H12I3N3O5
Molecular Weight	682.95 g/mol
Synonyms	5-Acetamido-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic Acid; Iopamidol Intermediate; AD-101; 2,4,6-Triiodo-5-[(2-hydroxyethyl)carbamoyl]-N-(2-aminoacetyl)isophthalamic Acid; 5-[[(2-Hydroxyethyl)amino]carbonyl]-N-(2-aminoacetyl)-2,4,6-triiodo-1,3-benzenedicarboxamide; Ioversol Related Compound; Non-Ionic Contrast Media Intermediate; Iohexol Impurity
EINECS	Contact for details

Quality Control

Our 3-[(Aminoacetyl)Amino]-5-[[(2-Hydroxyethyl)Amino]Carbonyl]-2,4,6-Triiodobenzoic Acid is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for pharmaceutical intermediate use, with a focus on purity and impurity profile control. Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and heavy metals are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.