Description

cis-10,11-Dihydroxy-10,11-Dihydrocarbamazepine is a key pharmaceutical intermediate and metabolite of the anticonvulsant drug carbamazepine. Its primary value lies in its critical role in drug metabolism studies, analytical reference standards, and the synthesis of novel therapeutic agents. This compound is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers specializing in active pharmaceutical ingredients (APIs) and high-purity fine chemicals.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of carbamazepine and its metabolites in biological matrices and pharmaceutical formulations.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Serves as a critical metabolite standard in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the metabolic pathway of carbamazepine.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and process development of carbamazepine and related derivative compounds.
• Analytical Chemistry: Utilized in method development and validation for HPLC, LC-MS, and other chromatographic techniques in quality control laboratories.
• Biomedical Research: Applied in preclinical and clinical studies investigating the efficacy, safety, and mechanism of action of antiepileptic drugs.

Basic Information

Product Name	cis-10,11-Dihydroxy-10,11-Dihydrocarbamazepine
CAS No.	58955-94-5
Molecular Formula	C15H14N2O3
Molecular Weight	270.28 g/mol
Synonyms	10,11-Dihydro-10,11-dihydroxycarbamazepine; CBZ-diol; Carbamazepine-10,11-dihydrodiol; 10,11-Dihydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; cis-Carbamazepine dihydrodiol; 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10,11-dihydroxy-, (10R,11S)-rel-; Carbamazepine metabolite (10,11-dihydrodiol)
EINECS	Contact for details

Quality Control

Our cis-10,11-Dihydroxy-10,11-Dihydrocarbamazepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.