Description

Protamine B, Acipenser Gueldenstaedtii is a highly purified, low molecular weight protein derived from the sperm of the Acipenser gueldenstaedtii (Russian sturgeon) species. This compound is valued for its strong cationic nature and ability to bind and neutralize heparin, making it a critical agent for controlling blood coagulation. It is essential for manufacturers and researchers in the pharmaceutical and biotechnology sectors who require a reliable, high-purity heparin antagonist for therapeutic formulations, diagnostic applications, and advanced biomedical research.

Application

• Pharmaceutical Antidote: Primary use as a heparin reversal agent in cardiovascular surgery, dialysis, and other medical procedures to restore normal clotting time.
• Biomedical Research: Used as a tool in biochemical and cell biology studies involving polyanions, nucleic acid precipitation, and protein purification.
• Drug Delivery Systems: Explored as a component in controlled-release formulations and nanoparticle systems due to its polycationic properties.
• Diagnostic Reagents: Incorporated into in-vitro diagnostic kits and assays for the detection and quantification of heparin activity.
• Cell Culture & Tissue Engineering: Utilized to modify surfaces for cell adhesion and growth in specialized tissue culture applications.

Basic Information

Product Name	Protamine B, Acipenser Gueldenstaedtii
CAS No.	58739-75-6
Molecular Formula	Contact for details
Molecular Weight	~4,000 - 6,000 Da (Approx.)
Synonyms	Protamine B; Sturgeon Protamine B; Clupeine B; Salmine B; Ichthyoprotamine B; Protamine Sulfate (from sturgeon); Fish Protamine; Heparin Antagonist Protein
EINECS	Contact for details

Quality Control

Our Protamine B is produced and tested under strict quality management systems to ensure it meets the high standards required for pharmaceutical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and biological activity. We adhere to relevant guidelines for biological sourcing and can provide material suitable for GMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to standard
Assay (Heparin Neutralization)	≥ 90% of labeled potency
Protein Content (Biuret)	≥ 90%
pH (1% Solution)	6.0 - 8.0
Loss on Drying	≤ 8.0%
Residue on Ignition	≤ 2.0%
Bacterial Endotoxins	< 5.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.