Description

Tertiapin CAS NO 58694-52-3 is a potent and selective peptide toxin that acts as a high-affinity blocker of inward-rectifier potassium (Kir) channels. This specificity makes it an invaluable research tool for studying ion channel physiology and pharmacology. It is primarily utilized by pharmaceutical researchers and academic institutions in neuroscience, cardiovascular research, and drug discovery programs.

Application

• Neuroscience Research: Used to study the role of specific Kir channels (e.g., Kir1.1, Kir3.1/3.4) in neuronal excitability, synaptic transmission, and neurological disorders.
• Cardiovascular Pharmacology: Employed as a pharmacological tool to investigate the function of Kir channels in cardiac cells and vascular smooth muscle, relevant to arrhythmias and hypertension.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening assays to identify novel Kir channel modulators.
• Cellular Physiology Studies: Applied in patch-clamp electrophysiology experiments to characterize native and recombinant Kir channel currents.
• Biochemical Research: Used in binding studies to determine receptor affinity and for the structural characterization of potassium channel pores.

Basic Information

Product Name	Tertiapin
CAS No.	58694-52-3
Molecular Formula	C124H193N39O34
Molecular Weight	~2740.1 g/mol
Synonyms	Tertiapin-Q; TPN; TPN-Q; Apis mellifera Tertiapin; Honey bee venom peptide tertiapin; Kir channel blocker tertiapin; Inward rectifier potassium channel blocker tertiapin
EINECS	Contact for details

Quality Control

Our Tertiapin is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and functional activity data. We adhere to rigorous in-house quality protocols to guarantee batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (Kir channel blockade)
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.