Description

(2-Fluoro-Phenyl)-Propynoic Acid Ethyl Ester is a versatile fluorinated organic building block characterized by its phenyl ring, fluorine substituent, and esterified propynoic acid moiety. This compound is valued for its role as a key synthetic intermediate in the development of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a fluorinated aromatic scaffold for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Acts as a building block for fluorinated organic semiconductors and liquid crystal compounds, contributing to improved electronic properties and device performance.
• Cross-Coupling Reactions: The alkyne and ester functional groups make it a suitable substrate for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create complex molecular architectures.
• Fluorine Chemistry Studies: Employed in academic and industrial laboratories to study the effects of fluorine introduction on chemical reactivity and physical properties in organic synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of custom fluorinated compounds and small-scale GMP batches.

Basic Information

Product Name	(2-Fluoro-Phenyl)-Propynoic Acid Ethyl Ester
CAS No.	58686-74-1
Molecular Formula	C11H9FO2
Molecular Weight	192.19 g/mol
Synonyms	Ethyl 3-(2-Fluorophenyl)propiolate; 2-Fluorophenylpropiolic Acid Ethyl Ester; Ethyl (2-Fluorophenyl)propynoate; 3-(2-Fluorophenyl)prop-2-ynoic acid ethyl ester; Propiolic acid, 3-(2-fluorophenyl)-, ethyl ester; NSC 405124; AI3-52300
EINECS	Contact for details

Quality Control

Our (2-Fluoro-Phenyl)-Propynoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.