Description

(3-Trifluoromethyl-Phenyl)-Propynoic Acid Ethyl Ester is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries requiring high-purity intermediates for research and production, such as medicinal chemistry and material science, are the primary users of this product.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the unique properties of the fluorine atom.
• Material Science Research: Serves as a precursor for advanced organic materials, including liquid crystals, polymers, and organic semiconductors.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for studying biological systems and drug-target interactions.
• Cross-Coupling Reactions: Acts as an effective substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex molecular architectures.
• Fluorine Chemistry Studies: A valuable reagent for academic and industrial research focused on incorporating fluorinated motifs into organic molecules.

Basic Information

Product Name	(3-Trifluoromethyl-Phenyl)-Propynoic Acid Ethyl Ester
CAS No.	58686-69-4
Molecular Formula	C₁₂H₉F₃O₂
Molecular Weight	242.19 g/mol
Synonyms	Ethyl 3-[3-(Trifluoromethyl)phenyl]propiolate; 3-(3-Trifluoromethylphenyl)propiolic Acid Ethyl Ester; Ethyl (3-Trifluoromethylphenyl)propiolate; m-(Trifluoromethyl)phenylpropiolic Acid Ethyl Ester; 3-(m-Trifluoromethylphenyl)propynoic Acid Ethyl Ester; Ethyl 3-(3-Trifluoromethylphenyl)prop-2-ynoate; 58686-69-4; EINECS 261-402-9
EINECS	261-402-9

Quality Control

Our (3-Trifluoromethyl-Phenyl)-Propynoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.